See the process explained
Monday, January 28, 2008
Sunday, January 27, 2008
Device able to pull stem cells from blood - UPI.com
In the study, published in the British Journal of Haematology, the researchers implanted the device in a living rat and they were able to capture stem cells straight out of the bloodstream,
"One of our ultimate goals is to develop an implantable device that will selectively remove metastatic cells from the blood," King said in a statement.
Device able to pull stem cells from blood - UPI.com
Friday, January 25, 2008
Approval for stem cell heart trial - Telegraph
British surgeons will next month begin ground-breaking research which could lead to improved chances of survival and quality of life for millions of heart attack patients.
A team at Bristol University has been given the go ahead to inject stem cells into the hearts of patients during bypass operations.
Thursday, January 24, 2008
George Daley on Korean stem cells' true source on Technorati
George Daley on Korean stem cells' true source on Technorati
This video explains why it was so hard for the Koreans to tell that SNCT did not occur in the creation of their stem cell line.
91. Disgraced Korean Cloner Accidentally Created Novel Stem Cells | Stem Cell Research | DISCOVER Magazine
To create an embryonic stem cell line using SCNT, a biologist sucks out the nucleus of an egg cell and replaces it with the nucleus of another cell—ideally one taken from the patient in need—creating a patient-specific stem cell line. Ongoing attempts to create human stem cell lines using SCNT have yet to achieve success.
Another process, called parthenogenesis, could yield stem cell lines that are genetically matched to a patient—in this case, the egg donor. In parthenogenesis, an egg is prodded to develop into an embryo without fertilization. Human parthenogenetic embryos are not viable—they run into developmental snags and cannot give rise to a person—but the stem cells derived from these embryos could still have research or therapeutic value.
Hwang claimed his stem cells did not result from parthenogenesis, but George Daley, head of the study, showed that the genome of Hwang’s cell line has a genetic signature that indicates it sprang from a parthenogenetic embryo.
Since 2004, several groups have reported creating stem cell lines through parthenogenesis. But Daley says his study shows “with very, very high certainty that the first Hwang line was in fact also the world’s first parthenogenetic line.”
Wednesday, January 02, 2008
HEART CELLS GENERATED FROM STEM CELLS
One of the main goals of stem cell research is to re-grow damaged tissue with fresh tissue that is genetically matched to the patient. This would not only prevent rejection of the implanted tissue but also get around the problem of the chronic shortage of human organs for transplant. In April, a team of British scientists at the Heart Science Centre at Harefield Hospital in Middlesex, UK, led by the world's leading heart surgeon Sir Magdi Yacoub, turned stem cells from bone marrow into functioning heart cells and then used these to make tissue that worked like a heart valve. This marks a significant step towards growing whole replacement hearts from stem cells, an objective that Yacoub said could be achieved in just 10 years.
Tags: stem cells, heart cells, Sir Magdi Yacoub
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Biomaterial scaffolds provide cues to Regenerating Endochondral vs. Intramembraneous Bone
Healing critical-size defects (defects that would not otherwise heal on their own) in intramembraneous bone, the flat bone type that forms the skull, is a vivid demonstration of new techniques devised by researchers at John Hopkins University to use hESCs for tissue regeneration.
Using mesenchymal precursor cells isolated from hESCs, the Hopkins team steered them into bone regeneration by using "scaffolds," tiny, three-dimensional platforms made from biomaterials
Physical context, it turns out, is a powerful influence on cell fate. Nathaniel S. Hwang, Jennifer Elisseeff, and colleagues at Hopkins demonstrated that by changing the scaffold materials, they could shift mesenchymal precursor cells into either of the body's osteogenic pathways: intramembraneous, which makes skull, jaw, and clavicle bone; or endochondral, which builds the "long" bones and involves initial formation of cartilage, which is then transformed into bone by mineralization.
It appears that material in the environment, the scaffolds, can influence the generation of different cell types for ESC. Usually, growth factors etc have been used so this is a different approach.
Tags: ESC, intramembraneous, endochondral, bone, stem cells, embryonic stem cells
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