Wednesday, March 14, 2007

The creepy solution to the stem-cell debate. - By William Saletan - Slate Magazine

The creepy solution to the stem-cell debate. - By William Saletan - Slate Magazine: "The second proposal, presented by council member William Hurlbut"

How could we create functioning parts of an embryo without the whole? By turning off one of the genes that guide embryo formation. Hurlbut's first choice is the human equivalent of cdx2, the gene in mice that directs the formation of the placenta. Without cdx2, the embryonic mouse cells divide but fail to take the shape of a mouse. The plan would be to follow the recipe for cloning—put the nucleus of a body cell into a gutted egg cell—but turn off cdx2. Then, once the cell begins to divide, reactivate the gene, too late to organize the embryo but early enough to make stem cells.

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