The good news is that real, beating cardiomyocytes can be grown from undifferentiated stem cells, and large quantities of these cells with distinctly human characteristics can be obtained from human embryonic stem cells, as Mummery's talk proved. These differentiated cells will permit screens for drugs that bolster the numbers of cardiomyocytes produced and that help cardiomyocytes engraft and survive. Thus, although this progress may not signal the arrival of effective therapies, it may mark the true beginning of their development.
The good news is also that the real work of heart repair is beginning. The tough answers are beginning to come out. Now, we can suspect that varying results might be caused by mis-labeling cells. Now, we know that the heart is a difficult but not impossible place to use stem cells, and that stem cells can form heart cells.
Tags: Heart, Cardiomyocytes, Mummery, ISSCR.
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